When symptoms of bladder pain and heartburn may be caused by acidic food...

...treat the food, not human body



kalcium glicerofoszfát tartalmú étrend-kiegészítő kapszula

Tough on the food, gentle on the body

Neutra: Q&A

Neutra is a food supplement in capsule form containing calcium glycerophosphate which neutralizes acids in foods. Taking Neutra before eating acidic foods can help to reduce or relieve symptoms in people whose medical conditions are exacerbated by acid consumption.

Many people are sensitive to food acid. Neutralizing the acid from food and beverages may allow people to remain comfortable when eating those foods.

Calcium glycerophosphate raises the pH of acidic foods and thus neutralizes the acid contained in these foods. It does not reduce acid production in the stomach, nor does it make acid in the stomach more alkaline in nature, so it needs to be taken prior to eating foods with a high acid content. By reducing the acidity of the food before it enters the body, Neutra may  can assist in alleviating symptoms caused by several different conditions.

By lowering the acid content of foods, Neutra may relieve symptoms of conditions in which acidity in the body can cause problems. Upper digestive conditions like heartburn and GERD are often exacerbated by eating acidic foods, causing people suffering from these conditions to give up foods they love and that are nutritious. These symptoms may be moderated or relieved with Neutra. Interstitial cystitis (IC) (or Bladder Pain syndrome, BPS), a painful inflammatory bladder condition, is also exacerbated by acidic foods in some patients.

Neutra works on the food, not on the body, and must be taken with food.

The active ingredient in Neutra is FDA Generally Recognized as Safe (GRAS)  mineral and is also listed in the Food Chemicals Codex (FCC). 

Before eating highly acidic foods, take one or two Neutra capsules. Neutra can be used every time you eat acidic foods. The active ingredient in Neutra is considered to be generally safe, but before beginning any supplement, contact your physician for approval.

  • Calcium (from calcium glycerophosphate) 130 mg (15%)
  • Phosphorus (from calcium glycerophosphate) 100 mg (10%)

Symptoms of Bladder Pain Syndrome (BPS) = Intestitial Cystitis (IC) (1)

  • bladder / pelvic pain
  • urge to urinate
  • frequent urination
  • nocturnal urination (nocturia)

Foods/Beverages Particularly Strong in Triggering/Aggravating Symptoms of Bladder Pain (2,3)

Neutra_savas ital-bor
alcohol: wine, sparkling wine, beer
Neutra_savas ital_narancslé
citrus fruit (juice): orange (juice), grapefruit (juice), lemon
Neutra_savas étel-paradicsom
tomato-based dishes: tomato (sauce), pizza, spaghetti
Neutra_savas ital-kávé
caffeine and soda drinks: coffee, tea (with caffeine), cola
spicy foods: chili, vinegar; Thai, Indian, Mexican food

Food Sensitivity is Very Common in IC

90-95% of IC patients and 77% of patients with prostate / pelvic pain were sensitive to various foods / beverages. 3.4


Acid Reduction Expected from Taking Two or Three Neutra Capsules? *

Quantity Food/Beverage 2 Capsules 3 Capsules
180 ml
180 ml
tea with lemon
120 ml
100% appple juice
120 ml
apple juice with low acidity
120 ml
orange juce
120 ml
tomato juice
240 ml
240 ml
240 ml
cola light
240 ml
120 ml
1/2 cup (120 ml)
tomato sauce
6 table spoons (90 ml)
red wine and vinegar dressing
1/2 cup (120 ml)
sweet & sour sauce
2 spoons(30 ml)
barbeque sauce
1/4 cup (60 ml)
pizza sauce
1 spoon (15 ml)
1 spoon (15 ml)
steak sauce
2 spoons (30 ml)
1/2 cup (120 ml)
peeled tomatoes with basil

*Based on data from Prelief caplets containing the same active ingredient. Source: https://www.prelief.com/faq/

Results of Clinical Trials with Calcium Glycerophosphate

Calcium Glycerophosphate (CaGP) reduced the symptoms exacerbated by acidic food / drinks in aptients with Bladder Pain Syndrome (Interstitial Cystitis) by up to 90%  5.6 *

The Effect of Calcium Glycerophosphate (CaGP) on Exacerbating Symptoms of Bladder Pain Syndrome (percentage of patients)

203 IC patients who completed a dietary diary for 3 months to identify problem foods received 690 mg of CaGP (2 Prelief caplets) for 4 weeks before eating problem foods, while keeping a voiding diary and reporting urgency and pain in urination. 5.6 * The study were performed with Prelief containing the same active ingredient. 5.6

The pain and discomfort measured with the Likert scale decreased from 5.3 to 3.6, and the urgency of urination decreased from 5.3 to 4.1 after CaGP. 5.6

Calcium glycerophosphate and sodium bicardone (baking soda) reduced  Bladder Pain Syndrome symptoms 5.6

CaGP  alleviated symptoms and improved quality of life in patients with hyperactive bladder sensitive to acidic foods,  7.8 *

After three weeks  CaGP significantly improved

  • quality and / or quantity of sleep
  • available travel destinations
  • freedom to dress
  • performing routine tasks
  • access to entertainment activities

In a double-blind, placebo-controlled study, 58 patients with overactive bladder (voiding frequency> 8/24 h, involuntary (urine) leakage> 1/24 h) received 3 x 670 mg CaGP daily for 3 weeks with food. Patients completed an Incontinence Questionnaire and a Voiding  Diary. 7 *

CaGP reduced symptoms of diarrhea-dominant irritable bowel syndrome (IBS) 9 *

Randomizált vizsgálatban 54 IBS beteg kapottt CaGP-t vagy placebo-t 4 hétig.
Mindegyik vizit alkalmával a betegek jelentették az IBS tüneteit, a bélmozgások
jellemzőit, valamint az életminőséget (elégedettséget, társadalmi aktivitásokat, szocializációt, kényelmet). 9*

CaGP significantly improved the following parameters of quality of life:

  • happiness
  • difficulty in falling asleep
  • strong movement restriction
  • food / drink restriction
  • comfort of social / family activities
  • avoiding work / main activities
  • avoiding outdoor activities
  • participation in community meetings

Mi a Neutra kapszula összetétele?

  • 345 mg kiválóan felszívódó kalcium  glicerofoszfát (CaGP) (ebből 65 mg kalcium + 50 mg foszfor) + 35 mg  inulin
  • Az inulin fokozza a CaGP felszívódását
  • Két Neutra kapszula a napi szükséglet 15%-át, ill. 10%-át biztosítja kalciumból, ill. foszforból

Mechasims of Action of CaGP

  • mechanisms of action not entirely known
  • increases the pH value of the acidic foods 
  • does not affect production and pH value of stomach acid

When do We Recommend the Neutra Capsule?

  • if we do not know acidity of food we will be eating  (restaurant, guest)
  • if we can’t prepare our usual food (travel, vacation)
  • if we are sensitive to many foods from our healthy diet
  • if we want to add one (more) tomato to the salad

Taking Neutra should not justify irresponsible diet or lifestyle in case of bladder or bowel problems.


Who do We Recommend the Neutra Capsule?

Neutra-IC-vizelési inger

intersziciális cisztitis (IC) 


prostatitis / pelvic pain


hyperactive bladder 


 irritable bowel syndrome (IBS)

What is the Difference between CaGP and Heartburn Drugs?

  • CaGP does not affect gastric acid
  • Gastric acid is essential for digestion and protection against bacteria

Why do We Recommend the Neutra Capsule?

  • Calcium and phosphorus in optimal proportions
  • Effective: Clinical studies reported reduction in  symptoms and improvement in  quality of life
  • It affects food, not human body: it helps to prevent problems before they occur
  • Safe, free from side effects


  1. Bogart LM et al. J Urol 2007 Feb; 177(2): 450-456
  2. Friedlander Ji et al. Br J Urol Internat 2012 ; 10 9 : 1584-1591
  3. Shorter B et al. J Urol 2007 2007 Juzl;178: 145-152
  4. Herati As et al. J Urol 2009 Vol. 181, No. 4, Suppl.: 22
  5. Whitmore KE. Rev Urol. 2002; 4(suppl 1): S28–S35      
  6. Bologna RAet al. Urology 57 (Supplement 6A), June 2001: 119
  7. http://akpharma-scientific.com/new/oab-abstract.doc.pdf
  8. http://akpharma-scientific.com/new/OAB-Stats-2-06.pdf  
  9. http://akpharma-scientific.com/new/IBS_final_report_6.14.05r.pdf
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