Why is it Important to Deal with Varicose Veins?

Frequent, can lead to serious complications.

  • In Western Europe, varicose veins affect 25–33% of women and 10–20% of men. 1.2 In Hungary, the incidence of varicose veins is close to 50%. 3
  • The most common complication is inflammation of the varicose vein, inflammatory obstruction, prolonged wound healing, chronic leg ulcer. 1
  • Surveys show that 1 out of 100 people develops at one stage of leg ulcer life. 1

Stages, Sings and Symptoms of Varicose Disease

From spider veins to venous ulcers

In 1994, a new classification sys1tem, CEAP, was developed in the USA based on the clinical picture (C), etiological factors (E), anatomical extent of the disease (A) and pathophysiological background (P). 1

  • Signs: tired, heavy legs, leg pain, itching, leg cramps, ankle and leg swelling
  • Symptoms: spider veins, varicose veins (wide, curvy) veins, edema (swelling), redness of the legs, leg ulcer
  • Risk factors: hereditary predisposition;  age; female, pregnancy, birth control pills; standing or permanent sitting, sedentary lifestyle;  diet poor in fiber; warm weather; obesity; venous thrombosis

What Can We Do to Prevent Varicose Veins?

  • Weight reduction
  • Stop smoking / drinking alcohol.
  • Physical Exercise. Swimming, walking on flat surface, jogging, cycling are the best.
  • Exercises for Varicose Veins
  • Natural herbal remedies
  • Control visits. Annual checks by physician recommended for risk factors.

Therapeutic Options for Varicose Veins

  • Conservative base therapy: compression treatment, venous exercises, drugs / dietary supplements, counseling. 4
  • Surgical treatment: traditional varicectomy, endovascular interventions, deep vein surgery.
  • Sclerotization: fluid sclerotherapy, foam sclerotherapy. 4

The active Ingredients of Venoptim are the Best-proven Venoactive Agents

Venoptim contains the best-proven representative of the internationally recommended venoactive ingredient groups: flavonoids (diosmin), saponins (horse-chestnut extract), and other plant extractss (grape seed extract). Venoptim also contains centella asiatica (gotu-cola) which increases the production of collagen, (the latter improves microcirculation).

Nemzetközileg javasolt természetes venoaktív hatóanyagok

Additive Effects with Various Venous-specific Mechanisms of Action

  • Diosmin: venospecific anti-inflammatory effect, lymphatic effect; 4.5
  • Horse chestnut extract: inhibits the breakdown of hyaluronic acid which plays an important role in anti-inflammatory and tissue regeneration; 6,7
  • Grape seed extract: inhibits collagen and elastin degradation, increasing the elasticity and resistance of the vessel wall; 8
  • Centella asiatica: enhances collagen production. 6

Clinical Results with the Active IIngredients in Venoptim

  • Diosmin is the best-proven venoactive drug.
  • Grape seed extract quickly relieved the symptoms of varicose disease.
  • Horse chestnut extract reduced edema in venous insufficiency to a similar extent as compression stockings.
  • Centella asiatica improved microcirculation in venous hypertension.

Ingredients in Venoptim Tablet

500 mg micronized diosamin, 100 mg horse chestnut, 100 mg grape seed extract,  60 mg Centella asiatica

The quantitative composition reflects two main priorities: high diosmin content and once daily dosing. Diosmin is a venoactive substance with the highest level of clinical evidence.

Why is Venoptim Special?

Proven, Quality, Logical

  • Proven active ingredients from Worldwide leaders in manufacturing
  • Quality micronized diosmin: 70% <2 microns, meets the standards of the  European Pharmacopoeia
  • Logical combination: potential for additive effects
  • Convenient: once-daily dosage 

References

  1. Carpentier PH et al. Prevalence, risk factors, and clinical patterns of chronic venous disorders of lower limbs: A population-based study in France Journal of Vascular Surgery 40: 650-659, 2004
  2. Rabe E et al. Bonner Venenstudie der Deutschen Gesellschaft für Phlebologie* Epidemiologische Untersuchung zur Frage der Häufigkeit und Ausprägung von chronischen Venenkrankheiten in der städtischen und ländlichen Wohnbevölkerung. Phlebologie 32:1-13, 2003
  3. Bihari I., Tornóci L., Bihari P. Az alsó végtagi varicositas hazai epidemiológiai felmérése. Érbetegségek 9:57-62, 2002;
  4. Sándor T. Orvosi Hetilap 151 (4): 131–139, 2010;
  5. Nicolaides A et al. Management of Chronic Venous Disorders of the Lower Limb. Guidelines according to Scientific Evidence. International Angiology 33 (2): 126-139, 2014;
  6. Szendrei K, Csupor D. Növnyi szerek a keringési betegséges prevenciójában és kezelésében (II. rész)Komplementer Medicina 3, 2008;
  7. Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency. Facino RM et al. Arch Pharm (Weinheim). 328(10):720-724. 1995;
  8. Weseler A, Bast A.Masquelier’s grape seed extract: from basic flavonoid research to a well-characterized food supplement with health benefits. Nutrition Journal 16 (5), 2017;.
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