The Four Pillars of Bone Health
Calcium: The Bone Building Material
All cells and tissues need calcium. In addition to ensuring bone strength , it plays a major role in the regulation of cellular processes, hormone formation, muscle and nerve trigger, and blood coagulation. 1, 2 Human body does not produce calcium, so it is necessary to replenish the amount consumed, primarily from food.
Magnesium: Calcium's Pair
Magnesium plays an important role in each step of vitamin D activation and in the production of parathyroid hormone which regulates calcium levels. In case of magnesium deficiency, calcium will not (only) be incorporated where it is needed, but also where it is not (in the blood vessels, joints, or soft tissues) – this results in arteriosclerosis. Magnesium balances the absorption and utilization of calcium. 3-5
Vitamin D: The Key to Calcium Absorption
Vitamin D contributes to:
- the normal absorption of calcium and phosphorus
- maintaining normal calcium levels
- maintaining normal bone and tooth structure
- maintaining normal structure of teeth
- maintaining healthy muscle function
- normal immune system
- normal cell division 6
Vitamin K2: Directs the Calcium We Consume to Where It's Needed
Vitamin K2 (menaquinone, MK) activates two calcium transport proteins:
- activated calcitonin helps direct calcium and incorporate it into the bone. Vitamin K2 supplementation can stop or reverse bone loss;
- activated matrix-Gla protein (MGP) helps to remove calcium from the vascular wall and soft tissues which helps in peventing atherosclerosis. 7, 8
Vitamins D3 and K2, as well as Magnesium, Play an Important Role in Regulating Calcium Levels
Regulation of calcium levels is largely based on the action of three hormones (parathyroid hormone, vitamin D, and calcitonin).
When calcium level is too low, parathyroid hormone increases it. Magnesium plays an important role in the production of parathyroid hormone.
If calcium level is too high, the thyroid gland raises the production of calcitonin – this helps to incorporate calcium into the bones. Vitamin D is required for the production of calcitonin and vitamin K2 is essential for its activation. 5, 9, 10
Why Do We Need the Co-ordinated Effects of the Four Agents for Bone and Cardiovascular Health?
Calcium alone will not be absorbed adequately. 11
- Calcium + Vitamin D3 may increase the risk of cardiovascular events 12,13
- Calcium (and Vitamin D3): friend or foe? It depends on vitamin K2.8
- Magnesium is needed to activate vitamin D. 4, 5
Vitamin D3- és K2: the Untapped Potential
What could be achieved with an optimal level of vitamin D3 and K2?
The lower limit of the desired range of vitamin D3 levels for calcium metabolism is 75 nmol / l. Increasing vitamin D3 level from 37.5-50 nmol / l to 75-100 nmol / l would result in a spectacular reduction in the incidence of the most widespread and difficult to treat diseases, and in overall mortality.14, 15
What Makes Osteo-Master Tablet Special?
- Effective: High content of Vitamin K2 and D3
- Proven Active Ingredients: Contains the brands of Vitamin K2 and D3 used in many clinical trials 17, 18
- Quality: MenaQ7 Crystals (95% purity, min 99.5% MK-7, 100% trans form) 19
- Convenient: once daily dosing
Active ingredient in one tablet: 100 µg vitamin K2 (MenaQ7), 50 µg (2000 IU) vitamin D3, 120 mg calcium, 60 mg magnesium.
Quantitative composition reflects two major priorities: high vitamin K2 and D3 content, and once daily dosing. Recognizing the importance of vitamins K2 and D3 is one of the greatest achievements of the last decade.
Who Should Supplement with Osteo-Master Tablet?
If you are taking calcium, magnesium, vitamin D3, or vitamin K2, you should consider taking the rest.
The use of Osteo-Master tablets is recommended to those suffering from and / or at risk of vitamin D3 / vitamin K2 / magnesium deficiency related conditions / diseases, and to women over 40 years of age. 20, 21
One tablet a day.
Pregnant and nursing mothers and those taking anticoagulant drugs should consult their physician before using this product.
- Flynn A. The role of dietary calcium in bone health. Proc Nutr Soc 2003 Nov;62(4):851-8.
- Renner E. Dairy calcium, bone metabolism, and prevention of osteoporosis. J Dairy Sci 1994, 77, 3498-3505.
- Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J 2012 Feb; 5 (Suppl 1): i3–i14
- Rude RK, Shils ME. Magnesium. In Modern Nutrition in Health and Disease (eds M.E. Shills et al.) 223-247 (2006)
- Gröber U és mtsai. Magnesium in Prevention and Therapy. Nutrients 2015 Sep; 7(9): 8199–8226.
- Nair R, Maseeh A. Vitamin D: The “sunshine” vitamin. J Pharmacol Pharmacother 2012 Apr-Jun; 3(2): 118–126.
- Vermeer C. Vitamin K: the effect on health beyond coagulation – an overview. >Food Nutr Res 2012; 56: 10
- Vitamin K2 Monograph. Alternative Medicine Review Volume 14, Number 3 2009, 284-293
- Anderson PH, May BK, Morris HA. Vitamin D Metabolism: New Concepts and Clinical Implications. Clin Biochem Rev 2003 Feb; 24(1): 13–26.
- Maresz K. Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health Integr Med (Encinitas). 2015 Feb; 14(1): 34–39.
- Cashman KD. Calcium intake, calcium bioavailability and bone health. Br J Nutr 2002 May;87 Suppl 2:S169-77.
- Bolland MJ. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis BMJ 2010; 341 :c3691
- Bolland MJ. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ 2011; 342: d2040
- Takács I. és mtsai. Hazai konszenzus a D-vitamin szerepéről a betegségek megelőzésében és kezelésében. Orvosi Hetilap 2012 153. Évf.. Szupplementum 5–26.
- Grant, W. B., Cross, H. S., Garland, C. F., et al.: Estimated benefit of increased vitamin D status in reducing the economic burden of disease in western Europe. Prog. Biophys. Mol. Biol., 2009, 99, 104–113
- Geleijnse JM és mtsai. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr 2004 Nov;134(11):3100-5.
- Knappen MH és mtsai. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis Int. 2013 Sep;24(9):2499-507.
- Knappen MH és mtsai. Menaquinone-7supplementation improves arterial stiffness in healthy postmenopausalwomen. A double-blind randomised clinical trial. Thromb Haemost 2015 May;113(5):1135-44.
- Badmaev V. MenaQ7 Crystals: Ingredient innovation rationale. http://menaq7.com/wp-content/uploads/2015/10/Nutracos_2012.pdf
- Seelig M, Rosanoff A. The Magnesium Factor. New York, Avery 2003.
- Holick MF. Vitamin D Deficiency. New Engl J Med 2007; 357 (3): 266–81.